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Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism...

Flynn, Ryan Paz, Katelyn Du, Jing Reichenbach, Dawn K Taylor, Patricia A Panoskaltsis-Mortari, Angela Vulic, Ante Luznik, Leo MacDonald, Kelli K P Hill, Geoffrey R ...

Published in Blood

Chronic graft-versus-host disease (cGVHD) remains a major complication following allogeneic bone marrow transplantation (BMT). The discovery of novel therapeutics is dependent on assessment in preclinical murine models of cGVHD. Rho-associated kinase 2 (ROCK2) recently was shown to be implicated in regulation of interleukin-21 (IL-21) and IL-17 sec...

Natural killer cell immunotherapy to target stem-like tumor cells

Grossenbacher, Steven K. Canter, Robert J. Murphy, William J.

Published in Journal for ImmunoTherapy of Cancer

Advances in cancer immunotherapy are leading to its increasing and successful application for the treatment of solid–tissue cancers. Despite the recent advances there are still significant barriers, in particular, evidence for significant tumor heterogeneity, both genetic and epigenetic that limit long-term efficacy. Subpopulations of “stem-like” t...

Effect of Microneedle Pretreatment on Topical Anesthesia: A Randomized Clinical Trial.

Ornelas, Jennifer Foolad, Negar Shi, Vivian Burney, Waqas Sivamani, Raja K

Published in JAMA dermatology

Mouse host unlicensed NK cells promote donor allogeneic bone marrow engraftment.

Alvarez, Maite Sun, Kai Murphy, William J

Published in Blood

Natural killer (NK) cells exist as subsets based on expression of inhibitory receptors that recognize major histocompatibility complex I (MHCI) molecules. NK cell subsets bearing MHCI binding receptors for self-MHCI have been termed as "licensed" and exhibit a higher ability to respond to stimuli. In the context of bone marrow transplantation (BMT)...

A systematic review of low-level light therapy for treatment of diabetic foot ulcer.

Tchanque-Fossuo, Catherine N Ho, Derek Dahle, Sara E Koo, Eugene Li, Chin-Shang Isseroff, R Rivkah Jagdeo, Jared

Published in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Diabetes mellitus (DM) is a significant international health concern affecting more than 387 million individuals. A diabetic person has a 25% lifetime risk of developing a diabetic foot ulcer (DFU), leading to limb amputation in up to one in six DFU patients. Low-level light therapy (LLLT) uses low-power lasers or light-emitting diodes to alter cel...

Treatment of melanoma in-transit metastases with combination intralesional interleukin-2, topical imiquimod, and tretino...

Leventhal, Jonathan S Odell, Ian D Imaeda, Suguru Maverakis, Emanual King, Brett A

Published in JAAD case reports

The Need for Greater Regulation, Guidelines, and a Consensus Statement for Tattoo Aftercare.

Liszewski, Walter Jagdeo, Jared Laumann, Anne E

Published in JAMA dermatology

Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats.

Arzi, Boaz Mills-Ko, Emily Verstraete, Frank J M Kol, Amir Walker, Naomi J Badgley, Megan R Fazel, Nasim Murphy, William J Vapniarsky, Natalia Borjesson, Dori L ...

Published in Stem cells translational medicine

This study is the first to demonstrate the safety and efficacy of fresh, autologous, adipose-derived stem cell systemic therapy for a naturally occurring, chronic inflammatory disease in cats. The findings demonstrate that this therapy resulted in complete clinical and histological resolution or reduction in clinical disease severity and immune mod...

Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity.

Shanker, Anil Pellom, Samuel T Jr Dudimah, Duafalia F Thounaojam, Menaka C de Kluyver, Rachel L Brooks, Alan D Yagita, Hideo McVicar, Daniel W Murphy, William J Longo, Dan L ...

Published in Cancer research

Cancer immunotherapy shows great promise but many patients fail to show objective responses, including in cancers that can respond well, such as melanoma and renal adenocarcinoma. The proteasome inhibitor bortezomib sensitizes solid tumors to apoptosis in response to TNF-family death ligands. Because T cells provide multiple death ligands at the tu...

A Method for Comprehensive Glycosite-Mapping and Direct Quantitation of Serum Glycoproteins.

Hong, Qiuting Ruhaak, L Renee Stroble, Carol Parker, Evan Huang, Jincui Maverakis, Emanual Lebrilla, Carlito B

Published in Journal of proteome research

A comprehensive glycan map was constructed for the top eight abundant glycoproteins in plasma using both specific and nonspecific enzyme digestions followed by nano liquid chromatography (LC)-chip/quadrupole time-of-flight mass spectrometry (MS) analysis. Glycopeptides were identified using an in-house software tool, GPFinder. A sensitive and repro...

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