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Identification of Equine Lactadherin-derived Peptides That Inhibit Rotavirus Infection via Integrin Receptor Competition...

Civra, Andrea Giuffrida, Maria Gabriella Donalisio, Manuela Napolitano, Lorenzo Takada, Yoshikazu Coulson, Barbara S Conti, Amedeo Lembo, David

Published in The Journal of biological chemistry

Human rotavirus is the leading cause of severe gastroenteritis in infants and children under the age of 5 years in both developed and developing countries. Human lactadherin, a milk fat globule membrane glycoprotein, inhibits human rotavirus infection in vitro, whereas bovine lactadherin is not active. Moreover, it protects breastfed infants agains...

Does wound eversion improve cosmetic outcome?: Results of a randomized, split-scar, comparative trial.

Kappel, Stefani Kleinerman, Rebecca King, Thomas H Sivamani, Raja Taylor, Sandra Nguyen, UyenThao Eisen, Daniel B

Published in Journal of the American Academy of Dermatology

Wound eversion was not significantly associated with improved overall scar assessments by blinded observers or patient assessment.

Reprint of: Recent advances in cytomegalovirus: an update on pharmacologic and cellular therapies.

Boeckh, Michael Murphy, William J Peggs, Karl S

Published in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

The 2015 Tandem American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplant Meetings provide an opportunity to review the current status and future perspectives on therapy for cytomegalovirus (CMV) infection in the setting of hematopoietic stem cell transplantation (HSCT). After many years during which...

Patient-centered, direct-access online care for management of atopic dermatitis: a randomized clinical trial.

Armstrong, April W Johnson, Mary Ann Lin, Steven Maverakis, Emanual Fazel, Nasim Liu, Fu-Tong

Published in JAMA dermatology

New models of health care delivery for dermatological care have the potential to increase access and improve patient-centered outcomes. To compare effectiveness of a direct-access, online model for follow-up dermatologic care in pediatric and adult patients with atopic dermatitis with that of in-person office visits. This was a 1-year, randomized c...

Light emitting diode-generated blue light modulates fibrosis characteristics: fibroblast proliferation, migration speed,...

Mamalis, Andrew Garcha, Manveer Jagdeo, Jared

Published in Lasers in surgery and medicine

Blue light is part of the visible light spectrum that does not generate harmful DNA adducts associated with skin cancer and photoaging, and may represent a safer therapeutic modality for treatment of keloid scars and other fibrotic skin diseases. Our laboratory previously demonstrated that light-emitting diode (LED) red and infrared light inhibits ...

Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a ne...

Fujita, Masaaki Zhu, Kan Fujita, Chitose K Zhao, Min Lam, Kit S Kurth, Mark J Takada, Yoko K Takada, Yoshikazu

Published in The Journal of biological chemistry

Integrins are activated by signaling from inside the cell (inside-out signaling) through global conformational changes of integrins. We recently discovered that fractalkine activates integrins in the absence of CX3CR1 through the direct binding of fractalkine to a ligand-binding site in the integrin headpiece (site 2) that is distinct from the clas...

Recent advances in cytomegalovirus: an update on pharmacologic and cellular therapies.

Boeckh, Michael Murphy, William J Peggs, Karl S

Published in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

The 2015 Tandem American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplant Meetings provide an opportunity to review the current status and future perspectives on therapy for cytomegalovirus (CMV) infection in the setting of hematopoietic stem cell transplantation (HSCT). After many years during which...

A large scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum

Gao, R Zhao, S Jiang, X Sun, S Zhao, S Gao, J Borleis, J Willard, S Tang, M Cai, H ...

Published in Science Signaling

Utilizing custom-designed galvanotaxis chambers to study directional migration of prostate cells.

Hsin-Ya Yang Tina La Rivkah Isseroff

Published in Journal of Visualized Experiments

The physiological electric field serves specific biological functions, such as directing cell migration in embryo development, neuronal outgrowth and epithelial wound healing. Applying a direct current electric field to cultured cells in vitro induces directional cell migration, or galvanotaxis. The 2-dimensional galvanotaxis method we demonstrate ...

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice...

Mirsoian, Annie Bouchlaka, Myriam N Sckisel, Gail D Chen, Mingyi Pai, Chien-Chun Steven Maverakis, Emanuel Spencer, Richard G Fishbein, Kenneth W Siddiqui, Sana Monjazeb, Arta M ...

Published in The Journal of experimental medicine

Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine storm. We found that aging was accompanied by increases in visceral fat similar to that seen in young obese (ob/ob or diet-induced obese [DIO]) ...

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