Selvaraj, Vimal Soundarapandian, Mangala M Chechneva, Olga Williams, Ambrose J Sidorov, Maxim K Soulika, Athena M Pleasure, David E Deng, Wenbin
Published in
The Journal of biological chemistry
Poly(ADP-ribose) polymerase-1 (PARP-1) has been implicated in the pathogenesis of several central nervous system (CNS) disorders. However, the role of PARP-1 in autoimmune CNS injury remains poorly understood. Therefore, we studied experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis in mice with a targeted deletion of PA...
Campbell, M Chang, Pc Huerta, S Chie Izumiya Davis, R Tepper, Cg Kevin Kim Shevchenko, B Wang, Dh Jung, Ju
...
Published in
Journal of Biological Chemistry
The Kaposi sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is a multifunctional protein with roles in gene regulation and maintenance of viral latency. Post-translational modification of LANA is important for functional diversification. Here, we report that LANA is subject to arginine methylation by protein arginine ...
Chang, Pei-Ching Yoshihiro Izumiya Wu, Chun-Yi Fitzgerald, Latricia D Campbell, Mel Ellison, Thomas J Lam, Kit S Luciw, Paul A Kung, Hsing-Jien
Published in
Journal of Biological Chemistry
Saegusa, Jun Akakura, Nobuaki Wu, Chun-Yi Hoogland, Case Ma, Zi Lam, Kit S Liu, Fu-Tong Takada, Yoko K Takada, Yoshikazu
Published in
The Journal of biological chemistry
Secretory phospholipase A2 group IIA (sPLA2-IIA) plays an important role in the pathogenesis of inflammatory diseases. Catalytic activity of this enzyme that generates arachidonic acid is a major target for development of anti-inflammatory agents. Independent of its catalytic activity, sPLA2-IIA induces pro-inflammatory signals in a receptor-mediat...
Hamza, Ms Reyes, Ra Yoshihiro Izumiya Wisdom, R Kung, Hj Luciw, Pa
Published in
Journal of Biological Chemistry
alpha-, beta-, and gamma-Herpesviruses encode putative viral protein kinases. The herpes simplex virus UL13, varicella-zoster virus ORF47, and Epstein-Barr virus BGLF4 genes all show protein kinase domains in their protein sequences. Mutational analysis of these herpesviruses demonstrated that the viral kinase is important for optimal virus growth....
Majumdar, M Tarui, T Shi, B Akakura, N Ruf, W Yoshikazu Takada
Published in
Journal of Biological Chemistry
Plasmin is a major extracellular protease that elicits intracellular signals to mediate platelet aggregation, chemotaxis of peripheral blood monocytes, and release of arachidonate and leukotriene from several cell types in a G protein-dependent manner. Angiostatin, a fragment of plasmin(ogen), is a ligand and an antagonist for integrin alpha(9)beta...
Civra, Andrea Giuffrida, Maria Gabriella Donalisio, Manuela Napolitano, Lorenzo Takada, Yoshikazu Coulson, Barbara S Conti, Amedeo Lembo, David
Published in
The Journal of biological chemistry
Human rotavirus is the leading cause of severe gastroenteritis in infants and children under the age of 5 years in both developed and developing countries. Human lactadherin, a milk fat globule membrane glycoprotein, inhibits human rotavirus infection in vitro, whereas bovine lactadherin is not active. Moreover, it protects breastfed infants agains...
Fujita, Masaaki Takada, Yoko K Takada, Yoshikazu
Published in
The Journal of biological chemistry
Integrin αvβ3 plays a role in insulin-like growth factor 1 (IGF1) signaling (integrin-IGF1 receptor (IGF1R) cross-talk) in non-transformed cells in anchorage-dependent conditions. We reported previously that IGF1 directly binds to αvβ3 and induces αvβ3-IGF1-IGF1R ternary complex formation in these conditions. The integrin-binding defective IGF1 mut...
Fujita, M Ieguchi, K Davari, P Yamaji, S Taniguchi, Y Sekiguchi, K Takada, Yk Yoshikazu Takada
Published in
Journal of Biological Chemistry
Integrin αvβ3 plays a role in insulin-like growth factor-1 (IGF1) signaling (integrin-IGF1 receptor (IGF1R) cross-talk). The specifics of the cross-talk are, however, unclear. In a current model, "ligand occupancy" of αvβ3 (i.e. the binding of extracellular matrix proteins) enhances signaling induced by IGF1 binding to IGF1R. We recently reported t...
Fujita, Masaaki Ieguchi, Katsuaki Cedano-Prieto, Dora M Fong, Andrew Wilkerson, Charles Chen, Jane Q Wu, Mac Lo, Su-Hao Cheung, Anthony T W Wilson, Machelle D
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Published in
The Journal of biological chemistry
Insulin-like growth factor-1 (IGF1) is a major therapeutic target for cancer. We recently reported that IGF1 directly binds to integrins (αvβ3 and α6β4) and induces ternary complex formation (integrin-IGF1-IGF1 receptor (IGF1R)) and that the integrin binding-defective mutant of IGF1 (R36E/R37E) is defective in signaling and ternary complex formatio...
