J, Saegusa S, Yamaji K, Ieguchi Cy, Wu Ks, Lam Ft, Liu Yk, Takada Y, Takada
Published in
Journal of Biological Chemistry
It has been proposed that ligand occupancy of integrin alphavbeta3 with extracellular matrix ligands (e.g. vitronectin) plays a critical role in insulin-like growth factor-1 (IGF-1) signaling. We found that expression of alphavbeta3 enhanced IGF-1-induced proliferation of Chinese hamster ovary cells in serum-free conditions (in the absence of vitro...
Wu, Pl Lee, Sc Chuang, Cc Mori, S Akakura, N Wu, Wg Yoshikazu Takada
Published in
Journal of Biological Chemistry
Severe tissue necrosis with a retarded wound healing process is a major symptom of a cobra snakebite. Cardiotoxins (CTXs) are major components of cobra venoms that belong to the Ly-6 protein family and are implicated in tissue damage. The interaction of the major CTX from Taiwan cobra, i.e. CTX A3, with sulfatides in the cell membrane has recently ...
Fujita, Masaaki Zhu, Kan Fujita, Chitose K Zhao, Min Lam, Kit S Kurth, Mark J Takada, Yoko K Takada, Yoshikazu
Published in
The Journal of biological chemistry
Integrins are activated by signaling from inside the cell (inside-out signaling) through global conformational changes of integrins. We recently discovered that fractalkine activates integrins in the absence of CX3CR1 through the direct binding of fractalkine to a ligand-binding site in the integrin headpiece (site 2) that is distinct from the clas...
Haudenschild, Dominik R Hong, Eunmee Yik, Jasper H N Chromy, Brett Mörgelin, Matthias Snow, Kaylene D Acharya, Chitrangada Takada, Yoshikazu Di Cesare, Paul E
Published in
The Journal of biological chemistry
Cartilage oligomeric matrix protein (COMP) is an important non-collagenous cartilage protein that is essential for the structural integrity of the cartilage extracellular matrix. The repeated modular structure of COMP allows it to "bridge" and assemble multiple cartilage extracellular matrix components such as collagens, matrilins, and proteoglycan...
