The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer tar...
...
Published in Molecular cancer therapeutics
The αvβ3 integrin, expressed on the surface of various normal and cancer cells, is involved in numerous physiologic processes such as angiogenesis, apoptosis, and bone resorption. Because this integrin plays a key role in angiogenesis and metastasis of human tumors, αvβ3 integrin ligands are of great interest to advances in targeted therapy and can...