Schreiber, Claire A Sakuma, Toshie Izumiya, Yoshihiro Holditch, Sara J Hickey, Raymond D Bressin, Robert K Basu, Upamanyu Koide, Kazunori Asokan, Aravind Ikeda, Yasuhiro
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Published in
PLoS pathogens
Adeno-associated viruses (AAV) have evolved to exploit the dynamic reorganization of host cell machinery during co-infection by adenoviruses and other helper viruses. In the absence of helper viruses, host factors such as the proteasome and DNA damage response machinery have been shown to effectively inhibit AAV transduction by restricting processe...
Toth, Zsolt Brulois, Kevin Lee, Hye-Ra Izumiya, Yoshihiro Tepper, Clifford Kung, Hsing-Jien Jung, Jae U
Published in
PLoS pathogens
The establishment of latency is an essential step for the life-long persistent infection and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV). While the KSHV genome is chromatin-free in the virions, the viral DNA in latently infected cells has a chromatin structure with activating and repressive histone modifications that promote late...