Hsia, Da Tepper, Cg Pochampalli, Mr Hsia, Ey Chie Izumiya Huerta, Sb Wright, Me Chen, Hw Kung, Hj Yoshihiro Izumiya
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Published in
Proceedings of the National Academy of Sciences
Localized chromatin modifications of histone tails play an important role in regulating gene transcription, and aberration of these processes leads to carcinogenesis. Methylated histone lysine residues, a key player in chromatin remodeling, are demethylated by the JmjC class of enzymes. Here we show that JMJD5 (now renamed KDM8), a JmjC family memb...
Bhatt, Ap Wong, Jp Weinberg, Ms Host, Km Giffin, Lc Buijnink, J Van Dijk, E Yoshihiro Izumiya Kung, Hj Temple, Br
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Published in
Proceedings of the National Academy of Sciences
Viruses depend upon the host cell for manufacturing components of progeny virions. To mitigate the inextricable dependence on host cell protein synthesis, viruses can modulate protein synthesis through a variety of mechanisms. We report that the viral protein kinase (vPK) encoded by open reading frame 36 (ORF36) of Kaposi s sarcoma-associated herpe...
Maverakis, Emanual Menezes, Juscilene S. Ametani, Akio Han, Mei Stevens, David B. He, Yong Wang, Yan Ono, Yoko Miyamura, Yoshinori Lam, Kit S.
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Published in
Proceedings of the National Academy of Sciences of the United States of America
To determine the role that competition plays in a molecular mimic’s capacity to induce autoimmunity, we studied the ability of naïve encephalitogenic T cells to expand in response to agonist altered peptide ligands (APLs), some capable of stimulating both self-directed and exclusively APL-specific T cells. Our results show that although the APLs ca...
Montague, Mj Li, G Gandolfi, B Khan, R Aken, Bl Searle, Sm Minx, P Hillier, Lw Koboldt, Dc Davis, Bw
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Published in
Proceedings of the National Academy of Sciences
Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with other cat breeds, wildcats, and other mammals. Based upon these comparisons, we identified positively selected genes enriched for...
Sungur, Cm Tang-Feldman, Yj Erik Ames Alvarez, M Chen, M Longo, Dl Pomeroy, C William Murphy
Published in
Proceedings of the National Academy of Sciences
Natural killer (NK) cells show differential functionality based on their capability of binding to self-MHC consistent with licensing. Here we show in vivo confirmation of the physiologic effects of licensing with differential effects of NK subsets on anti-murine cytomegalovirus (anti-MCMV) responses after syngeneic hematopoietic stem cell transplan...
Levy, Am Gilad, O Xia, L Yoshihiro Izumiya Choi, J Tsalenko, A Yakhini, Z Witter, R Lee, L Cardona, Cj
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Published in
Proceedings of the National Academy of Sciences
Marek s disease virus (MDV) is a highly pathogenic and oncogenic herpesvirus of chickens. MDV encodes a basic leucine zipper (bZIP) protein, Meq (MDV EcoQ). The bZIP domain of Meq shares homology with Jun/Fos, whereas the transactivation/repressor domain is entirely different. Increasing evidence suggests that Meq is the oncoprotein of MDV. Direct ...
Emanual Maverakis Beech, J Stevens, Db Ametani, A Brossay, L Van Den Elzen, P Mendoza, R Thai, Q Macias, Lh Ethell, D
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Published in
Proceedings of the National Academy of Sciences
It is not clear why the N-terminal autoantigenic determinant of myelin basic protein (MBP), Ac1-9, is dominant in the B1O.PL (H-2(u)) mouse, given its weak I-A(u)-MHC binding affinity. Similarly, how do high-affinity T cells specific for this determinant avoid negative selection? Because the MBP:1-9 sequence is embryonically expressed uniquely in t...